1. Highlights

    Higher levels of vitamin D are associated with lower digestive system cancer mortality. Urashima and colleagues randomized 417 patients with cancers of the digestive tract and found that vitamin D supplementation did not improve relapse-free survival. In an Editorial, Barry and colleagues ...


  2. Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers: The AMATERASU Randomized Clinical Trial

    This randomized clinical trial compares the effects of vitamin D supplementation vs placebo on 5-year relapse-free survival after surgical resection of stage I-III esophageal, gastric, small bowel, and colorectal cancers.

  3. Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial

    This phase 2 randomized clinical trial compares the effects of high-dose vs standard-dose vitamin D 3 added to standard chemotherapy on progression-free survival among patients with metastatic colorectal cancer.

  4. Association of HIV Preexposure Prophylaxis With Incidence of Sexually Transmitted Infections Among Individuals at High Risk of HIV Infection

    To evaluate the possibility that HIV preexposure prophylaxis (PrEP) might lead to behavioral changes that increase risk of non-HIV sexually transmitted infections (STIs), this cohort study investigates the incidence of chlamydia, gonorrhea, and syphilis among a population of Australian gay...

  5. Association of Patient Characteristics and Tumor Genomics With Clinical Outcomes Among Patients With Non–Small Cell Lung Cancer Using a Clinicogenomic Database

    This cancer epidemiology study links electronic health record (EHR) data with comprehensive genomic profiling to identify patient characteristics and gene alterations associated with overall survival, response to targeted and immune therapies, and other clinical outcomes in patients non–...

  6. Nurse Practitioner and Physician Assistant Waivers to Prescribe Buprenorphine and State Scope of Practice Restrictions

    This study uses SAMHSA data to describe the proportions of nurse practitioners and physician assistants with waivers to prescribe buprenorphine for treating opioid use disorder and associations with state regulations restricting their scope of practice.

  7. Physicians’ Trust in One Another

    This Viewpoint discusses the importance of trust between physicians for ensuring quality care and reducing physician burnout; shares physicians’ stories about trust and mistrust of their peers and colleagues; and proposes a set of initial principles intended to foster physician-physician...

  8. Why Physicians Should Trust in Patients

    This Viewpoint discusses the importance of reciprocal trust between patients and physicians, identifies reasons physicians may not trust their patients, and proposes ways physicians can communicate their trust directly to patients.

  9. Obesity Treatment, Beyond the Guidelines: Practical Suggestions for Clinical Practice

    This Viewpoint proposes a guideline-based approach to weight management counseling in primary care, emphasizing the need to avoid stigmatizing overweight and obesity, and the need for physician persistence in offering patients their attention, support, and individualized treatment.

  10. Nutrition Education in Medical School, Residency Training, and Practice

    This Viewpoint discusses the lack of nutrition education offered to medical students, despite the important role that physicians can and should play in advising patients on the topic, and proposes ways to integrate meaningful nutrition instruction into all phases of medical training.