1. Regular articleCardiovascular, pulmonary, and renal pathologyCD147/Basigin Deficiency Prevents the Development of Podocyte Injury through FAK Signaling

    Podocytes, which are susceptible to injury by various stimuli and stress, are critical regulators of proteinuric kidney diseases, regardless of the primary disease and pathogenesis. We further confirmed a significant correlation between urinary CD147/basigin (Bsg) levels and proteinuria in...

  2. Pericytes Act as Key Players in Spinal Cord Injury - ScienceDirect

  3. Regular articleImmunopathology and infectious diseasesNitrosative Stress Is Associated with Dopaminergic Dysfunction in the HIV-1 Transgenic Rat

    Supported by the;, the;Intramural Research Program, and the;at the NIH grant;.;Supported by the;, the;Intramural Research Program, and the;at the NIH grant;.

  4. Regular articleGastrointestinal, hepatobiliary, and pancreatic pathologyReceptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3)–Mixed Lineage Kinase Domain-Like Protein (MLKL)–Mediated Necropto

    Increased hepatic ischemia-reperfusion (IR) injury in steatotic livers is a major reason for rejecting the use of fatty livers for liver transplantation. Necroptosis is implicated in the pathogenesis of fatty liver diseases. Necroptosis is regulated by three key proteins: receptor-interact...

  5. Regular articleCell injury, repair, aging, and apoptosisUbiquitin-Specific Protease 15 Maintains Transforming Growth Factor-β Pathway Activity by Deubiquitinating Transforming Growth Factor-β Receptor

    Wound healing is a process of cutaneous barrier reconstruction that occurs after skin injury and involves diverse cytokines and cell types. Similar to several deubiquitinating enzymes, ubiquitin-specific protease 15 (;) can remove ubiquitin chains from specific proteins to rescue them from...

  6. Regular articleNeurobiologyCognitive Decline, Cerebral-Spleen Tryptophan Metabolism, Oxidative Stress, Cytokine Production, and Regulation of the Txnip Gene in a Triple Transgenic Mouse Model of Alzhe

    Pathologic inflammation in response to injury, infection, or oxidative stress is a proposed mechanism relating cognitive decline to dementia. The kynurenine pathway and thioredoxin-interacting protein (TXNIP) activity regulate inflammation and neurotoxicity in Alzheimer disease (AD). We ex...

  7. Regular articleMetabolic, endocrine, and genitourinary pathobiologyA Noncanonical Role for Plasminogen Activator Inhibitor Type 1 in Obesity-Induced Diabetes

    Obesity is a major risk factor for type 2 diabetes because of chronic hepatic inflammation and resultant insulin resistance. Hepatocyte growth factor (HGF) is responsible for resetting hepatic homeostasis after injury following activation by urokinase-type plasminogen activator (u-PA; enco...

  8. Regular articleVascular biology, atherosclerosis, and endothelium biologyChoriocapillaris Degeneration in Geographic Atrophy

    Early age-related macular degeneration (AMD) is characterized by degeneration of the choriocapillaris, the vascular supply of retinal photoreceptor cells. We assessed vascular loss during disease progression in the choriocapillaris and larger vessels in the deeper choroid. Human donor macu...

  9. CCN3/Nephroblastoma Overexpressed Is a Functional Mediator of Prostate Cancer Bone Metastasis That Is Associated with Poor Patient Prognosis - ScienceDirect

  10. Regular articleMachine learning, computational pathology, and biophysical imagingAutomated Identification and Quantification of Signals in Multichannel Immunofluorescence Images: The SignalFinder-IF P

    Supported by;Early Detection Research Network grant;,;Alliance of Glycobiologists for Cancer Detection grant;, and;Common Fund Glycoscience Program grant;(B.H.).;Supported by;Early Detection Research Network grant;,;Alliance of Glycobiologists for Cancer Detection grant;, and;Common Fund G...